Blue nevus‐like and blue nevus‐associated melanoma: a comprehensive review of the literature

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Tieche first described the common blue nevus in 1906.1 Blue naevi are benign proliferations of dendritic dermal melanocytes that actively produce melanin. The blue colour (ceruloderma) is due to the preferential scattering of shorter wavelengths of light by dermal melanin, a phenomenon known as the Tyndall effect.2 Malignant blue nevus (MBN) is a term first proposed by Allen et al. in 1953 to describe cases of melanoma with blue nevus‐like histological features.3 Several authors have since used the term to describe a variety of different entities, including malignant change in a pre‐existing blue nevus,4 melanoma arising at the site of a (previously excised) blue nevus,4 melanoma with blue nevus‐like histological features8 or a melanoma with an admixed, benign, blue nevus component.6 As there is heterogeneity in the histology of lesions classified as MBN, we prefer the terms blue nevus‐like melanoma (BNLM) if the malignancy has histological features resembling blue nevi, or blue nevus‐associated melanoma (BNAM) if it does not.

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