FDOPA Patterns in Adrenal Glands: A Pictorial Essay

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Abstract

18F-FDOPA is a well-established tool to explore pheochromocytomas. It tends to replace 123I-MIBG scan in metastatic pheochromocytomas, multiple endocrine neoplasia type 2-related tumors, succinate dehydrogenase [ubiquinone] iron-sulfur subunit-negative tumors, and succinate dehydrogenase[ZERO WIDTH SPACE]-positive lesions. To our knowledge, no study has characterized physiological and pathological adrenal glands with 18F-FDOPA from a quantitative point of view. We report the features of different normal and pathological adrenal glands with 18F-FDOPA. Within our series, only pheochromocytomas present a significantly increased uptake reflecting the high specificity of this tracer. Tumors such as adenomas or myelolipomas present no 18F-FDOPA significant accumulation. Interestingly, adrenal gland hyperplasia and solitary glands do not demonstrate compensatory uptake.

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