INCONTINENCE: How do β3-adrenoceptor agonists work in the bladder?
Data from an immunohistochemical study reveal abundant expression of β3-adrenoceptors on cholinergic nerves of the human urinary bladder. This finding suggests that the effects of β3-adrenoceptor agonists on overactive bladder are not mediated simply through direct inhibition of bladder smooth muscle cell excitability, but might involve a more complex mechanism, including an inhibitory effect on cholinergic nerve terminals.
Refers to Coelho, A. et al. Beta-3 adrenergic receptor is expressed in acetylcholine-containing nerve fibers of the human urinary bladder: an immunohistochemical study. Neurourol. Urodyn.http://dx.doi.org/10.1002/nau.23224 (2017)