Antibacterial Effect of Bacteriocin Isolated From Lactobacillus Plantarum ATCC 8014 on Postoperative Infection of Mandibular Fracture In Vivo

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Abstract

Objective:

The primary objective of this study was to verify the effects of bacteriocin in treatment of postoperative infection of mandibular fracture in vivo.

Methods:

Eighty-two mice were inoculated intravenously with staphylococcal suspensions. Bacterial cultures were obtained from implants. Blood samples were collected at 1, 2, 4, 6, and 8 hours after the injection of bacteriocins.

Results:

Bacteriocins have significant inhibitory effects on Staphylococcus aureus (P < 0.05) and there are significant differences interleukin (IL)-8 and IL-10 in serum (P < 0.05).

Conclusions:

Bacteriocin isolated from L plantarum may be one of promising ways to control postoperative infection of mandibular fracture in vivo.

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