68Ga-PSMA PET/CT in Osteosarcoma in Fibrous Dysplasia

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Fibrous dysplasia (FD) is a benign bone lesion with a rare but potential for malignant transformation. Neither 99mTc-MDP nor 18F-FDG PET/CT can differentiate between FD and areas of malignant transformation in FD. We described a case of osteosarcoma developing in FD with selective uptake of tracer in malignant transformation areas demonstrated on a 68Ga-PSMA PET/CT scan. Our case highlights the ability of 68Ga-PSMA PET/CT to map tumor neoangiogenesis in osteosarcoma arising in FD, which can have potential implications in prognostication, possibility of antiangiogenesis-based therapeutic options, and in response assessment following chemotherapy.

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