HIV cure strategies: response to ignore the central nervous system at your patients’ peril

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We read with interest the recent article published in AIDS by Gama et al.[1], highlighting evidence for a significant central nervous system (CNS) reservoir in simian immunodeficiency virus macaque models despite effective long-term peripheral viral suppression by antiretroviral therapy. This was followed by an informative editorial by Spector and Rappaport [2], cautioning those involved in HIV cure research not to overlook this important viral reservoir. Future cure strategies, which test the impact of interventions on measures of viral reservoir in peripheral body compartments, may not assume that they have the same efficacy in the CNS and thereby mitigate the effectiveness of HIV cure interventions.

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