Loss of β-cell mass is posited to occur gradually over a long period of time in preclinical type 1 diabetes mellitus, as the first signs of β-cell autoimmunity generally emerge several years before clinical presentation. This concept has recently been challenged by observations of acute loss of β-cell mass in late-phase preclinical disease.
Refers to Rodriguez-Calvo, T. et al. Increase in pancreatic proinsulin and preservation of beta cell mass in autoantibody positive donors prior to type 1 diabetes onset. Diabeteshttps://doi.org/10.2337/db16-1343 (2017)