Comparing Dopamine and Epinephrine in Pediatric Fluid Refractory Hypotensive Septic Shock

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We found the article published in a recent issue of Critical Care Medicine by Ramaswamy et al (1) interesting and thought provoking. It is a well-designed study, and it is an important contribution to an ongoing discussion in the pediatric critical care community regarding the optimal vasopressor in this patient population. We did have several concerns regarding the article, however, which are detailed below:
Overall, this research is an important contribution to the literature and will undoubtedly continue to prime the discussion for larger, multicenter trials comparing dopamine and epinephrine for septic shock.

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