Severe food allergies: can they be considered rare diseases?

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Food allergy is a very frequent disease, but its clinical spectrum is various. Differently from asthma and allergic rhinitis, an official definition of severe food allergy does not exist [1,2]: one can expect that such definition differs among each of the multifaceted aspects of food allergy. Surely, the severe manifestations are only a small part of the spectrum of food allergy. As examples, Food Protein-Induced Enterocolitis Syndrome (FPIES) is severe by definition [3], but only the patients sensitive to a large number of offending foods and/or with severe characteristics of the reaction can be considered with severe FPIES. Anaphylaxis is also an example of a generalized food-allergic manifestation, which can in some cases be life threatening and thus be considered a severe food allergy.
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