Pregnant women, neonates, and infants are at higher risk for severe infections due to vaccine-preventable diseases. Very young infants rarely respond well to vaccination due to poor immunogenicity and interference from maternal antibody. Maternal immunization protects the mother and fetus from disease and protects the infant through transplacental antibody transfer through the first 6 months of life. Currently, immunizations routinely recommended during pregnancy include inactivated influenza, tetanus toxoid, and acellular pertussis vaccines. Promising maternal vaccine candidates in development include a group B streptococcus vaccine and a respiratory syncytial virus vaccine. Birth Defects Research 109:379-386, 2017. © 2017 Wiley Periodicals, Inc.