Fluid Balance and Organ Failure in Acute Pancreatitis: Retrospective Cohort Study

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To the Editor:
Aggressive fluid therapy for acute pancreatitis is an important supportive treatment. However, a higher positive net fluid balance in critically ill patients can be associated with acute respiratory failure, acute renal failure, and increased mortality.1–3
Recent studies have questioned the value of aggressive fluid therapy for acute pancreatitis.4–7 Although fluid volume might be influenced by patient weight and fluid output, to our knowledge no study has yet taken these factors into account.
We investigated the optimal amount of fluid therapy for patients with acute pancreatitis, considering both net fluid balance and body mass index (BMI).

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