Susceptibility of Trichophyton mentagrophytes to Visible Light Wavelengths

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Abstract

OBJECTIVE:

To determine whether a blue light (405 nm) could inhibit the growth of Trichophyton mentagrophytes without using a photosensitizing material as part of the treatment protocol.

DESIGN:

Basic physiologic randomized trial using laboratory specimens (T mentagrophytes).

INTERVENTIONS/METHODS:

Plated on a growth medium, T mentagrophytes were exposed to 3 to 5 administrations of blue light at 20 J/cm2 over 28 hours. Following 7 days of incubation, colony-forming units were counted and compared with nonirradiated controls.

RESULTS:

The study found 3, 4, and 5 administrations of blue light produced significant inhibition of T mentagrophytes (P < .05); 4 and 5 applications produced the greatest inhibition of growth (84.7% and 93.6% kill rates, respectively).

CONCLUSIONS:

The application of 405-nm light at a dose of 20 J/cm2 is an effective in vitro inhibitor of T mentagrophytes. To give results similar to those seen when a photosensitizing material is included, 3 to 5 applications of this wavelength and dose condition delivered over 28 hours is likely needed.

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