Is there a role or target value for nutritional vitamin D in chronic kidney disease?

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Vitamin D is a key hormone for the maintenance of calcium and phosphate homeostasis. The term ‘vitamin’ is a misnomer, as Vitamin D is not an essential nutrient but is an endogenously produced classical hormone.1 Vitamin D has endocrine, paracrine and autocrine actions at its canonical target tissues of the skeleton, gastrointestinal tract and kidney. However, the vitamin D receptor (VDR) is very widely expressed, suggesting a broader role for vitamin D beyond mineral homeostasis; and the role of vitamin D in non‐classical target tissues has been the source of investigation.
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