Kidney transplant outcomes in HIV serodiscordant recipient pairs

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Excerpt

Kidney transplantation has been successfully employed in HIV+ patients with end-stage kidney disease [1]. However, allograft survival rates are less favourable than in the general kidney transplant population [2], which may relate to the high incidence of delayed graft function [3], acute graft rejection [2,4,5], or infection of the graft with HIV [6]. Use of less intensive immunosuppressive regimens and expanded criteria donors, drug–drug interactions between antiretroviral and immunosuppressive regimens, and persistent immune activation and inflammation may contribute to the increased rate of graft rejection [2,4,5,7–9]. In the absence of randomized clinical trials, useful insights may be gleaned from analyzing donor/recipient characteristics and graft outcomes in HIV serodiscordant recipient pairs of deceased-donor grafts.

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