Lack of efficacy of infliximab in the treatment of primary sclerosing cholangitis in inflammatory bowel diseases in childhood
In 2015, we completed a retrospective study (14 years) on pediatric patients affected by IBD and PSC (23 patients), considering the ones treated with IFX for their intestinal disease, to assess its clinical effectiveness in both IBD and PCS. Of the 23 patients, four (17.4%, three male), all of them with ulcerative colitis, were treated with IFX with the following schedule: induction with 5 mg/kg (intravenouslly) at weeks 0, 2, and 6, followed by maintenance treatment with 5 mg/kg (intravenouslly) every 8 weeks. Age at diagnosis of IBD was 7.21±5.32 years with a follow-up of 91.05±69.03 months. IFX was started after 5.72 years from the diagnosis of ulcerative colitis (range: 0.54–9.92 years), or for steroid-resistant/dependent or severe intestinal disease. The IFX was discontinued in all patients after 0.53±0.20 months (VI–IV infusion): in two patients because of poor control of the hepatobiliary disease [alanine aminotransferase 5.4×upper limit of normal (ULN), aspartate aminotransferase 4.3×ULN, γ-glutamyltransferase 9.8×ULN] with necessity to change therapy; in one patient because of adverse reaction (flushing of the face, skin rash, tachycardia, and fainting); and in one patient because of relapse of severe intestinal disease, with contextual evidence of lack of control of the hepatobiliary disease. In all patients, we found an increase in cytolysis and cholestasis during IFX therapy (Fig. 1). We also noticed in these patients poor control of intestinal disease with 1–2 episodes of mild–moderate intestinal relapses per patient, and need to start steroids and antibiotics repeated over time, with persistent use of other immunosuppressants in two patients (azathioprine). In one patient relapse of severe intestinal disease required colectomy. Hepatobiliary involvement in IBDs, in particular in pediatric patients, still remains a challenge for clinicians because of the difficulty to diagnose and manage both diseases with current drugs in use. Our limited experience shows that IFX is not effective in the control of PSC-associated with IBD in pediatric patients, as it does not change its clinical course or outcome. Increasing awareness of the underlying pathogenic mechanisms could open up new frontiers for controlling inflammation and progression of these diseases, and other biological drugs with different mechanisms of action (e.g. vedolizumab) could represent the future in the treatment of these patients.