Development of light-driven gas-forming liposomes for efficient tumor treatment

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Abstract

In this study, we report a gas-forming liposome containing 1H-1H-2H-perfluoro-1-hexene (PFH) and gold nanoparticles (AuNPs). These liposomes were rapidly destabilized by external near-infrared (NIR) light, as a result of the vaporization of PFH influenced by an AuNPs-mediated photothermal event. In particular, these liposomes showed the triggered release of the encapsulated D-(KLAKLAK)2 peptide drug. The experimental results demonstrated that the light-irradiated liposomes significantly enhanced in vitro photothermal and D-(KLAKLAK)2 peptide-mediated cell death of CAOV-3 tumor cells.

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