Beta-eudesmol reduces stem cell factor-induced mast cell migration

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Abstract

Previously, we showed the inhibitory effects of β-eudesmol on mast cell-mediated allergic inflammatory responses. Stem cell factor (SCF) participates in allergic reactions through the differentiation and migration of mast cells. However, the effects of β-eudesmol on SCF-mediated allergic reactions are poorly understood. Herein, we showed that a treatment of rat peritoneal mast cells (RPMCs) with β-eudesmol markedly suppressed SCF-induced mast cell migration and morphological alterations in a concentration-dependent manner. β-eudesmol also reduced F-actin formation. The activation of Fyn kinase, Rac1 GTPase, and p38 mitogen-activated protein kinases as increased by SCF was reduced by β-eudesmol. Moreover, β-eudesmol significantly abolished SCF-induced tumor necrosis factor-α and intercellular adhesion molecule-1 production without cytotoxicity. These results demonstrate that β-eudesmol has an anti-allergic inflammatory effect through the inhibition of mast cell migration and inflammatory cytokine production.

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