Gonadotropin levels in urine during early postnatal period in small for gestational age preterm male infants with fetal growth restriction

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Abstract

OBJECTIVE:

The objective of this study was to estimate gonadotropin concentrations in small for gestational age (SGA) male infants with the reactivation of the hypothalamic-pituitary-gonadal axis during the first few months of life that is important for genital development.

STUDY DESIGN:

We prospectively examined 15 SGA and 15 appropriate for gestational age (AGA) preterm male infants between 2013 and 2014 at Kyoto University Hospital. Gonadotropin concentrations (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) were measured in serial urine samples from the postnatal days 7 to 168 and compared between SGA and AGA infants using the Mann-Whitney test.

RESULTS:

A longitudinal analysis showed that SGA infants had higher LH and lower FSH concentrations (P = 0.004 and P = 0.006, respectively) than AGA infants.

CONCLUSION:

Male infants who are SGA at birth because of fetal growth restriction have gonadotropin secretion abnormalities in the first few months of life.

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