Distribution and Clearance of Blood Constituents after Intracerebral Hemorrhage in Rats: Mechanisms and Relevance for Functional Outcomes

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Abstract

Background and Objective

To evaluate the impact of blood clearance mechanisms on neurologic damage and functional outcomes after intracerebral hemorrhage (ICH) in rats.

Methods

A rat model of ICH was established through pre-cannulation and injection of autologous arterial blood into the caudate nucleus. Blood was supplemented with 6-amino-caproic acid (a procoagulant), low-molecular-weight heparin (an anticoagulant), or vehicle. Relationships between hematoma volume and edema size and neurologic damage were assessed at different times.

Results

At 6 hours and 24 hours, hematoma volume was greater in rats that received anticoagulant than in the other two groups (p < 0.01). No significant differences were observed at 3 days, 5 days, or 7 days (p > 0.05). At 6 hours and 24 hours, the Neurological Severity Score in the procoagulant group was significantly higher than in the other two groups (comparison between groups, p < 0.01); and no significant differences were found at other times (p > 0.05).

Conclusion

Enhanced clearance of leaked blood was associated with larger hematomas within the first 3 days of ICH and with less neurologic damage. The capacity to clear blood is an important determinant of functional recovery after ICH. Enhanced clearance may help reduce neurologic damage.

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