Propafenone for supraventricular arrhythmias in septic shock—Comparison to amiodarone and metoprolol

    loading  Checking for direct PDF access through Ovid

Abstract

Purpose:

The occurence of supraventricular arrhythmias associate with an unfavourable prognosis in septic shock. Propafenone could be a feasible antiarrhythmic.

Materials and methods:

Patients collected over a period of 24 months were divided into the three groups based on antiarrhythmic: Group1(amiodarone), Group2(propafenone), Group3(metoprolol). Type of arrhythmia, cardioversion rates, demographic, haemodynamic, laboratory parameters were recorded in the first 24 h. The outcome data were compared between the groups.

Results:

234 patients (99.1% ventilated) were included, the prevailing arrhythmia was acute onset atrial fibrillation (AF,69.7%). Except for the dosage of noradrenaline (0.35(0.14–0.78) in Group1(n = 142)vs 0.25(0.10–0.50),p < 0.01 in Group2(n = 78)vs 0.14(0.07–0.25)μg/kg·min,p < 0.05 in Group3(n = 14)) the ejection fraction of left ventricle, rates of renal replacement therapy, arterial lactate and procalcitonin levels were not different between the groups. The cardioversion rate in Group1(74%) was lower than in Group2(89%) and Group3(92%). ICU and 28-day mortalities of Group1 were not significantly higher than in Group2 and Group3. Multivariate analysis demonstrated higher 12-month mortality in Group1 than in Group2 (HR1.58(1.04;2.38),p = 0.03).

Conclusions:

Propafenone demonstrated a higher cardioversion rate than amiodarone with a similar impact on the outcome. Patients remaining in acute onset arrhythmia did not demonstrate significantly higher ICU, 28-day and 12-month mortalities compared to those successfully cardioverted or to those having chronic AF.

Related Topics

    loading  Loading Related Articles