RENAL PHYSIOLOGY: Burning calories to excrete salt

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Abstract

New findings challenge the dogma that high salt intake leads to increased thirst, water intake and diuresis. Titze and colleagues show that salt loading activates an adaptive regulatory network in the kidney, muscle and liver, which enables the reprioritization of energy metabolism to conserve plasma water in the setting of high salt intake.

Refers to Rakova, N. et al. Increased salt consumption induces body water conservation and decreases fluid intake. J. Clin. Invest.http://dx.doi.org/10.1172/JCI88530 (2017) | Kitada, K. et al. High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation. J. Clin. Invest.http://dx.doi.org/10.1172/JCI88532 (2017)

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