Incidental Prostate-Specific Membrane Antigen Uptake in a Peripheral Nerve Sheath Tumor

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Abstract

A 66-year-old man with recently diagnosed prostate cancer (Gleason score 9) was referred for 68Ga–prostate-specific membrane antigen (PSMA) PET/CT with prostate-specific antigen level of 7.5 μg/L. PET/CT demonstrated increased PSMA uptake (SUVmax 4.7) in a soft tissue density in the left adductor compartment. MRI and cytopathology of the biopsied soft tissue density was compatible with a peripheral nerve sheath tumor. This case illustrates that PSMA uptake can occur in a peripheral nerve sheath tumor and should be taken into consideration as a benign cause of PSMA uptake.

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