Patients suffering from severe 100% TBSA burns are particularly vulnerable to infection and multiple organ dysfunction syndrome, being on high risks of poor outcomes. Treatment of these patients remains to be a great challenge for burn physicians, and survivors of 100% TBSA burns generally have poor quality of life after burn. Since, to our knowledge, this is the first case report on the long-term follow-up of a 100% TBSA burn survivor, the authors are presenting the initial injury, treatment, and follow-up of this female patient during 27 years. She had received good first aid, successful fluid resuscitation, and effective antibiotic therapy. The wounds healed after 8 sessions of skin grafting by postburn day 108, and she was dismissed after 121 days. To promote her recovery, a structured rehabilitation plan was initiated immediately after the admission and conducted consistently throughout her postburn life. The authors evaluated her quality of life after 27 years’ follow-up using adapted Chinese version of the Burn Specific Health Scale—brief version and Chinese translation version of the Short Form-36, the results of which suggest that the patient is satisfied with her life in psychologic perspectives despite lower scores in physical aspects.