Endometrial cancer (EMCA) is the most common gynecologic malignancy, with an estimated 54,000 new cases and 10,000 deaths in the United States in 2015. Lymph node metastasis is the most significant prognostic factor in EMCA. Sentinel lymph node (SLN) mapping has become a well-accepted procedure in surgical oncology and may strike a balance between the risks and benefits of lymphadenectomy.Objective
The aim of this study was to review the current literature regarding the history, techniques, and clinical application of SLN mapping in EMCA.Evidence Acquisition
Evidence was obtained through systematic literature review through PubMed and ClinicalTrials.gov.Conclusions
Sentinel lymph node biopsy for EMCA is an accepted approach to the staging of this cancer; however, a consensus approach to the SLN biopsy technique and pathologic assessment is needed. Surgeons newly adopting the technique should proceed with caution and care to monitor outcomes.Target Audience
Obstetricians and gynecologists, family physiciansLearning Objectives
After completing this activity, the learner should be better able to describe the importance of lymph node metastasis in EMCA prognosis, recognize the various techniques for SLN biopsy, describe the history of the SLN, and recognize the potential clinical application for SLN biopsy in the treatment of EMCA.