Reply: physics cannot be disputed

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We read with interest the comments by Shirai et al.[1] on our recent publication in which we studied, on a theoretical basis, the pressure dependence of arterial stiffness index beta and cardio-ankle vascular index (CAVI) [2]. In our article, we demonstrated, given the same assumptions made in deriving CAVI [3], that β and CAVI show a residual dependence on blood pressure (BP). Given these assumptions, we provided corrected stiffness indices (β0 and CAVI0) that do not show this residual BP dependence [2]. We wish to address the concerns raised by Shirai et al.[1], in the context of our theoretical analysis [2].

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