Reply: physics cannot be disputed
We read with interest the comments by Shirai et al. on our recent publication in which we studied, on a theoretical basis, the pressure dependence of arterial stiffness index beta and cardio-ankle vascular index (CAVI) . In our article, we demonstrated, given the same assumptions made in deriving CAVI , that β and CAVI show a residual dependence on blood pressure (BP). Given these assumptions, we provided corrected stiffness indices (β0 and CAVI0) that do not show this residual BP dependence . We wish to address the concerns raised by Shirai et al., in the context of our theoretical analysis .