Meta‐analysis of the predictive value of DNA aneuploidy in malignant transformation of oral potentially malignant disorders
DNA aneuploidy is an imbalance of chromosomal DNA content that has been highlighted as a predictor of biological behavior and risk of malignant transformation in several types of human tissues,8 such as Barrett's esophagus, ulcerative colitis, colorectal adenomas, melanocytic skin nevi, cervical as well as oral lesions.9 DNA content, as evaluated using image cytometry (DNA‐ICM) and high‐resolution flow cytometry (DNA‐FCM), permits the detection of abnormal nuclear DNA content. Both DNA‐ICM and DNA‐FCM techniques have been considered appropriate for routine analysis in many clinical applications including OPMDs.6
So far, DNA aneuploidy in OPMDs has been shown to correlate strongly with severe dysplasia 8 and high‐risk lesions that appeared non‐dysplastic can be identified by ploidy analysis.6 Nevertheless, the prognostic value of DNA aneuploidy in predicting malignant transformation of OPMDs remains to be validated.
The aim of this systematic review and meta‐analysis was to assess the role of DNA aneuploidy in predicting malignant transformation in OPMDs.