A newly identified insertion-deletion variant of the B cell activating factor (BAFF)-encoding TNFSF13B gene leads to increased levels of soluble BAFF and is associated with the development of systemic lupus erythematosus. The discovery raises a number of compelling questions for further investigation.
Refers to Steri, M. et al. Overexpression of the cytokine BAFF and autoimmunity risk. N. Engl. J. Med. 376, 1615-1626 (2017)