CORRInsights®: Combined Administration of ASCs and BMP-12 Promotes an M2 Macrophage Phenotype and Enhances Tendon Healing
Generally, hand surgeons attempt to prevent adhesions through early mobilization. But we must also recognize that inflammation is the essential trigger and coordinator to the entire healing process, and macrophages play a key role in initiating this process . Although modulation of inflammation is an attractive prospect, it may create a ripple effect later in the healing process, resulting in poor tensile strength in the repaired tendon.
New approaches have emerged [4, 5, 7], which can be divided into three broad categories: (1) Mechanical strategies, (2) biological manipulation of adhesions, and (3) tissue engineering.