Patient‐reported outcome measures in oral lichen planus: A comprehensive review of the literature with focus on psychometric properties and interpretability
Little is known regarding the use of PROMs in patients with oral lichen planus (OLP), a common chronic inflammatory disease4 that can cause long‐standing painful ulceration of the oral mucosa6 and is also known to increase the risk of oral cancer development.8 The persistent painful symptoms of OLP can have significant negative impact on daily activities (eg eating, swallowing, speaking) but can also impair psychosocial functioning as well as patient's quality of life.9 Therefore, medical treatment, often in the form of long‐term use of topical corticosteroids or immunosuppressants, is required to reduce patient's painful symptoms.10
Clinical scoring systems (CSS) used in OLP have been comprehensively addressed in a recent review.11 Some of these CSS demonstrated good measurement properties for use in clinical studies of patients with OLP including Escudier severity scale (ESS)12 and reticulation‐erythema‐ulceration (REU) scoring system13 . However, very few studies focus mainly on the use and psychometric evidence of PROMs in OLP patients. Two reviews have previously investigated the use of PROMs in patients with oral mucosal diseases,15 but there remains no comprehensive assessment of the instruments used specifically in studies of OLP patients. The purposes of this study are to i) review the range of PROMs used for the assessment of oral symptoms, psychosocial status and quality of life in the OLP population and ii) assess their psychometric properties and interpretability.