rqt: an R package for gene-level meta-analysis

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Despite recent advances of modern GWAS methods, it is still remains an important problem of addressing calculation an effect size and corresponding p-value for the whole gene rather than for single variant.


We developed an R package rqt, which offers gene-level GWAS meta-analysis. The package can be easily included into bioinformatics pipeline or used stand-alone. We applied this tool to the analysis of Alzheimer's disease data from three datasets CHS, FHS and LOADFS. Test results from meta-analysis of three Alzheimer studies show its applicability for association testing.

Availability and implementation:

The package rqt is freely available under the following link: https://github.com/izhbannikov/rqt.



Supplementary information:

Supplementary data are available at Bioinformatics online.

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