Biogenic Ag@Pd core-shell nanoparticles were greenly synthesized within two plant extracts aiming at enhanced anticancer/bactericidal functions. These functions were verified for the two Pd@Ag biogenic core-shell nanoparticles (BCSnp) with constant Pd to several Ag contents. BCSnp were synthesized within two extracts of Almond nuts and Black Berry fruits, four samples each, through simple, low cost and echo friendly microwave route. The BCSnp Surface Plasmon Resonance (SPR) was detected via UV/visible spectrophotometer. Their morphology was assessed using High-Resolution Transmission Electron Microscope and Field Emission Scanning Electron Microscope supplemented with EDAX. Particle size/zeta potential of the achieved nanoparticles was measured. The active reducing groups were depicted by FTIR while XRD assessed nanoparticles crystallinity. The enhanced particle size distribution as proved by UV and band gap energies, imparted better functionality by the Almond extract compared to the berry one due to its protein content. Cytotoxicity against human breast cancer (MCF7) and liver cancer (HEPG2) cell lines were followed and compared to the normal Wish cells. The antimicrobial impact against gram-negative (G− veo) E. coli, gram-positive (G+ ve) S. aureus bacteria and mycotic strain C. albicans species were verified and compared to antibiotics. A significant inhibition of cancer cell growth of MCF 7 and HEPG2 compared to Wish normal cells and doxorubicin is assessed. A discriminative effect was recorded for G− ve compared to G+ ve, along with Mycotic strain C. albicans is achieved. The obtained BCSnp are proposed for cancer therapy and bactericidal applications with improved efficiency applying the nanomedicine approach. Tailorable properties can be obtained by tuning the individual structures.