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We thank Calò et al. [1] for the letter with interesting comments about our recently published article in the Journal of Hypertension[2]. Indeed, the elegant study performed in dialysis patients treated with green tea [3] supports our study in an experimental model of hypertension in rats (nitric oxide synthase inhibition by N-nitro-L-arginine methyl ester L-NAME) in which short-term green tea treatment induced a robust reduction in oxidative stress either vascular or systemically, reduced the sympathoexcitation to the kidney and significantly improved the baroreceptor function. Such alterations are present in dialysis patients as well as in our experimental model of hypertension, as both conditions are characterized by increased oxidative stress, clinical and experimental evidence indicate that green tea potentially targets the mechanisms that lead to sympathoexcitation and thereby improves cardiovascular function and hypertension, as proposed by Calò et al. [1,3].

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