modPhEA: model organism Phenotype Enrichment Analysis of eukaryotic gene sets

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Abstract

Motivation

Genome-scale phenotypic data are available for many model organisms, yet existing tools to functionally interpret gene sets from these phenotypic data are largely based on mutagenesis-derived phenotypes observed in mouse or human.

Results

Data from both mutagenesis and knockdown experiments are incorporated into modPhEA to allow users to perform enrichment analyses based on phenotypes observed in budding yeast (Saccharomyces cerevisiae), roundworm (Caenorhabditis elegans), fruit fly (Drosophila melanogaster), zebrafish (Danio rerio), mouse (Mus musculus) and humans (Homo sapiens). The phenotypes analysed can be customized to investigate complex traits and gene sets from any fully sequenced animal or fungal genome are also supported by modPhEA.

Availability and implementation

Freely available on the web at http://evol.nhri.org.tw/modPhEA/.

Contact

liaoby@nhri.org.tw

Supplementary information

Supplementary data are available at Bioinformatics online.

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