Atropine 0.5% eyedrops for the treatment of children with low myopia: A randomized controlled trial

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Abstract

Background:

This study aimed to assess the efficacy and safety of atropine 0.5% eyedrops (ATE) for the treatment of children with low myopia (LM).

Methods:

In this study, a total of 126 children with LM were randomly divided into an intervention group (administered 0.5% ATE) and a control group (administered a placebo), with 63 children in each group. The outcome measurements were changes in the spherical equivalent (SE), and axial length (AL), as well as adverse events (AEs).

Results:

Compared with placebo, administration of 0.5% ATE led to less progression in LM, as measured by SE, and less increase in AL (P < .01). In addition, no serious AEs occurred in both the groups.

Conclusion:

About 0.5% ATE was efficacious and safe for controlling myopia in children with LM.

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