Gangs and gang violence are a concerning cause of preventable injuries and death in the trauma community. The number of gangs and gang members has been on an upward trend since 2003 with an estimated 30,000 gangs in the United States. This includes approximately 850,000 gang members. Trauma centers are in a unique position to participate in the prevention of gang violence. This review compiles current, relevant literature on gangs and gang violence covering the following topics: prevention/intervention, contributing influences, and experiential reflections. The purpose of the literature review is to deepen understanding of gangs and gang violence and potentiate further research in this area in order to help promote successful prevention efforts. Trauma nurses can use this information in developing culturally sensitive, compassionate care and trauma centers will find this useful in the development of injury prevention programs aimed at the reduction of gang and street violence.