Trigonella foenum-graecumseed extract has demonstrated hormone modulatory activity, providing biological plausibility for relieving menopausal symptoms. The study aimed to assess efficacy of a standardizedT. foenum-graecumde-husked seed extract in reducing menopausal symptoms in healthy aging women. The study was a double-blind, randomized, placebo-controlled trial that recruited 115 women aged 40 to 65 years of which 59 were allocated to active (n= 54 completed) and 56 to placebo (n= 50 completed). Active treatment wasT. foenum-graecumde-husked seed extract,600 mg per day for 12 weeks. Outcome measures included Menopause-Specific Quality of Life (MENQOL) questionnaire, frequency of hot flushes and night sweats and serum estradiol levels. There was a significant reduction in menopausal symptoms in the active group compared with placebo as assessed by total MENQOL score (p< 0.001); reflected by significant improvements in the vasomotor (p< 0.001), psychosocial (p< 0.001), physical (p< 0.001) and sexual symptoms (p< 0.001) domains. Vasomotor outcomes correlated with hot flushes, the active group reporting significantly less daytime hot flushes and night sweats at 12 weeks (p< 0.001). The average estradiol levels were similar in both the active group and placebo group after treatment. This study demonstrated that this proprietaryT. foenum-graecumde-husked seed extract may reduce menopausal symptoms in healthy women.