L-Ornithine and L-lysine stimulate gastrointestinal motility via transient receptor potential vanilloid 1

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Abstract

Among basic amino acids, L-ornithine (Orn) and L-lysine (Lys) stimulated but L-arginine (Arg) suppressed gastrointestinal (GI) motility after oral administration. Orn- and Lys-induced GI motility stimulation was inhibited by either TRPV1 antagonist or TRPV1-knockout mice. The stimulatory effect of Orn and Lys on GI motility was also mediated by muscarinic acetylcholine receptor and nitric oxide synthase.

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