Tumor necrosis factor alpha-238G/A polymorphism and risk of breast cancer: An update by meta-analysis

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The association between the tumor necrosis factor-alpha gene (TNF-a) -238G/A polymorphism and the breast cancer has been analyzed in several studies, but the results have been inconclusive. We then performed a meta-analysis to get a precise estimation of the association.


Eight case–control studies with a total of 37,257 cases and 39,564 controls were identified by searching the ISI Web of Knowledge database and the PubMed database up to August 2014.


Overall, no association was found between TNF-alpha-238G/A polymorphism and breast cancer in any of genetic model (additive model OR = 1.06, 95%CI: 0.94–1.21, Pheterogeneity = .02; homozygous model OR = 1.04, 95%CI: 0.83–1.30, Pheterogeneity = .98; dominant model OR = 1.06, 95%CI: 0.92–1.21, Pheterogeneity = .01; recessive model OR = 1.04, 95%CI: 0.83–1.30, Pheterogeneity = .98). Furthermore, no significant association was identified when stratified by ethnicity (Caucasian, Asian).


This meta-analysis indicated that the TNF-alpha-238G/A polymorphism is not associated with breast cancer risk in the overall population.

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