Influence of childhood trauma on diagnosis and substance use in first-episode psychosis

    loading  Checking for direct PDF access through Ovid



Childhood trauma has been significantly associated with first-episode psychosis, affective dysfunction and substance use.


To test whether people with first-episode psychosis who had experienced childhood trauma, when compared with those who had not, showed a higher rate of affective psychosis and an increased lifetime rate of substance use.


The sample comprised 345 participants with first-episode psychosis (58% male, mean age 29.8 years, s.d. = 9.7).


Severe sexual abuse was significantly associated with a diagnosis of affective psychosis (χ2 = 4.9, P = 0.04) and with higher rates of lifetime use of cannabis (68% v. 41%; P = 0.02) and heroin (20% v. 5%; P = 0.02). Severe physical abuse was associated with increased lifetime use of heroin (15% v. 5%; P = 0.03) and cocaine (32% v. 17%; P = 0.05).


Patients with first-episode psychosis exposed to childhood trauma appear to constitute a distinctive subgroup in terms of diagnosis and lifetime substance use.

Declaration of interest


Related Topics

    loading  Loading Related Articles