Comment on “The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport”

    loading  Checking for direct PDF access through Ovid

Abstract

O’Brien et al. (Research Article, 24 February 2017, eaag1789) proposed a novel mechanism of primase function based on redox activity of the iron-sulfur cluster buried inside the C-terminal domain of the large primase subunit (p58C). Serious problems in the experimental design and data interpretation raise concerns about the validity of the conclusions.

Related Topics

    loading  Loading Related Articles