This study examined the influence of tactical and situational variables on offensive sequences during elite football matches. A sample of 68 games and 1694 offensive sequences from the Spanish La Liga, Italian Serie A, German Bundesliga, English Premier League and Champions League were analysed using chi-square and logistic regression analyses. Results revealed that counterattacks (OR=1.44; 95% CI: 1.13 to 1.83; P<0.01) and fast attacks (OR=1.43; 95% CI: 1.11 to 1.85; P<0.01) increased the success of an offensive sequence by 40% compared with positional attacks. The chance of an offensive sequence ending effectively in games from the Spanish, Italian and English Leagues were higher than in the Champions League. Offensive sequences that started in the pre-offensive or offensive zones were more successful than those started in the defensive zones. An increase of 1 second in the offensive sequence duration and an extra pass resulted in a decrease of 2% (OR=0.98; 95% CI: 0.98 to 0.99; P<0.001) and 7% (OR=0.93; 95% CI: 0.91 to 0.96; P<0.001), respectively in the probability of its success. These findings could assist coaches in designing specific training situations that improve the effectiveness of the offensive process.