Vitamin D in Orthopaedics

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Vitamin D plays a crucial role in bone metabolism through regulation of serum calcium and phosphate. Receptors for vitamin D have been found on osteoblasts and chondrocytes and trigger endochondral ossification and vascularization. Evidence also supports a role for vitamin D in neoplastic, neurodegenerative, vascular, and inflammatory processes 1 . Furthermore, recent literature argues for a beneficial role of vitamin D in skeletal health and function. Thus, vitamin D in orthopaedic populations is becoming increasingly recognized as important. Current screening recommendations for vitamin D deficiency by the American Academy of Orthopaedic Surgeons (AAOS) include select orthopaedic populations who were 50 years of age and older and those who have a diagnosis associated with decreased bone health (Table I) 2 .
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