Shedding light on the contribution of different c-fibre nociceptors to nocifensive behavior

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Behavioral assays play a central role in preclinical pain research. A major limitation of such assays is that they do not provide a quantitative measure of pain intensity. Hence, behavioral responses such as paw withdrawal, guarding, licking, jumping, vocalization, or changes in facial expression are commonly used as surrogate measures of pain intensity.7 However, whether different behavioral responses indicate different pain intensities or whether they solely reflect neural activity in a particular nociceptor subpopulation or simultaneous activity in multiple subsets of nociceptors is largely unclear.
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