Revascularization of ischaemia-injured myocardium is critical for functional recovery. A new study shows that endothelial cells of neovessels in the injured heart derive from pre-existing endothelial cells. This new finding focuses research on therapeutic strategies to direct the neovasculature to deliver oxygen and nutrients effectively to the ischaemic myocardium.
Refers to He, L. et al. Pre-existing endothelial cells mediate cardiac neovascularization after injury. J. Clin. Invest.http://dx.doi.org/10.1172/JCI93868 (2017)