Carcinoid Arising From the Teratomatous Bronchial Mucosa in a Mature Cystic Teratoma of the Ovary: A Case Report
Primary ovarian carcinoids are relatively uncommon, either pure (monodermal teratomas) or in association with mature cystic teratomas. Here we reported a unique case of carcinoid arising from the teratomatous bronchial mucosa in an ovarian mature cystic teratoma in a 22-year-old woman. This tumor showed a compact trabecular and nested growth pattern with salt-and-pepper chromatin pattern. Mitotic figures were identified (6/10 high power fields) and focal necrosis was present. Immunohistochemically the tumor cells were diffusely positive for TTF1 and CD56, focally positive for synaptophysin, and negative for chromogranin A and CDX2. Ki67 proliferation index was approximately 20% to 25%. This patient was alive with no evidence of disease at 3 years and 7 months after surgery. To our knowledge, this is the first case report of carcinoid arising from the teratomatous bronchial mucosa in an ovarian mature teratoma in the English literature.