Epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes

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Most of type 2 diabetes (T2D) is thought to be the result of interaction between genetic and environmental factors. However, the genetic components discovered to date can explain only a small proportion of the observed heritability. The “missing heritability” may be accounted for by rare variants, gene-environment interactions, and epigenetics.

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