The Management of Osteoporosis After Fragility Fracture: The Orthopaedic Perspective
Osteoporosis is the most common metabolic bone disease worldwide 1 . It is a result of an imbalance in bone formation and resorption leading to disruption of bone microarchitecture. This disruption of normal physiology ultimately results in increased fracture risk. The prevalence of osteoporosis and its associated fragility fractures have been progressively increasing, and this course is projected to continue from 2 million fractures in 2005 to a projected 3 million fractures in 2025 in the United States. Annually in the United States, osteoporosis is implicated in approximately 280,000 hip fractures, 540,000 vertebral fractures, 380,000 wrist fractures, and >800,000 fractures at other sites 2,3 . Fracture is the most common musculoskeletal diagnosis requiring hospital admission among the Medicare population 4 . The lifetime risk of any fragility fracture approaches 40% in Caucasian women and 13% for men who are ≥50 years of age 5 . In total, 50% of women and 25% of men who are ≥50 years of age will have an osteoporosis-related fracture in their lifetime 5 .