Making It Personal: Neoantigen Vaccines in Metastatic Melanoma

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Abstract

Somatic mutations in cancer can be translated into peptides, termed neoantigens, which can be recognized by the immune system as “foreign” epitopes. Two recent studies inNature(Sahin et al., 2017; Ott et al., 2017) examine the effects of neoantigen vaccines on patients with stage III or IV melanoma and demonstrate immunogenicity and intriguing clinical safety and efficacy data in phase I studies.

Somatic mutations in cancer can be translated into peptides, termed neoantigens, which can be recognized by the immune system as “foreign” epitopes. Two recent studies in Nature (Sahin et al., 2017; Ott et al., 2017) examine the effects of neoantigen vaccines on patients with stage III or IV melanoma and demonstrate immunogenicity and intriguing clinical safety and efficacy data in phase I studies.

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