Colorectal cancer remains a leading cause of cancer-related morbidity and mortality, with screening behavior found to be influenced by knowledge and other psychosocial attitudes. We recruited 784 participants 50 to 70 years of age. The intervention arm received a culturally sensitive, literacy-appropriate educational intervention by a promotora. Surveys were completed at baseline and 6 months post. Our intervention significantly increased knowledge at 6 months when compared with control (0.74 vs 0.18, P < .0001). We also report increase in perceived susceptibility to colorectal cancer and perceived benefits of colorectal cancer screening while decreasing sense of fatalism. Perceived barriers to screening did significantly increase.