Associations between body mass index and the risk of mortality from lung cancer: A dose–response PRISMA-compliant meta-analysis of prospective cohort studies

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Abstract

Background:

Whether body mass index (BMI) is associated with the risk of mortality from lung cancer (LC) is controversial, and the shape of dose–response relationship on this topic is not well-established. Thus, a dose–response meta-analysis was performed to clarify this association.

Methods:

A search of PubMed and EMBASE was conducted, and 2-stage random-effect dose–response model was used to yield summary relative risks and its shape.

Results:

Fifteen prospective cohort studies were eligible for inclusion criteria. The combined relative risks per 5 kg/m2 in BMI for risk of LC mortality is 0.94 (95% confidence interval] 0.92–0.96), and nonlinear association was found (Pnonlinearity < .0001), which indicated that compared with higher BMI, lower BMI showed higher LC mortality risk. Subgroup analyses revealed that this obesity paradox remained regardless of number of cases, follow-up duration, and study location, but this relationship was not observed among nonsmokers.

Conclusion:

A nonlinear association between BMI and the risk of LC mortality was found, and higher BMI participants have a lower risk of LC death than slim people.

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